Webmore about ENV-101 for PTCH-1 LOF cancer treatment. Clinical Trials We are developing ENV-101 for patients with tumor mutations in the Hedgehog pathway, which affect approximately 2% of all cancers. Mutations in this pathway can aberrantly activate downstream signaling resulting in proliferation, survival, and metastasis of cancer cells. WebOct 14, 2024 · Endeavor is partnered with xCures. Endeavor is currently looking at the PTCH1-LOF mutation. Regardless of your eligibility for the Endeavor trial, xCures will still send you a list of other treatment options that could work for your cancer mutation. This means that even if you are not eligible for the Endeavor trial, you will receive a list of other …

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